Concert Pharmaceuticals, Inc. (CNCE)

conpharmaConcert Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company that focuses on developing and manufacturing novel medicines by applying the company’s proprietary Deuterated Chemical Entity (DCE) Platform to compounds that have well-characterized pharmacological activity. This type of approach may enable less costly and more efficient drug discovery and clinical development compared to conventional small molecule drug research and development.

With the application of Concert’s extensive knowledge of deuterium chemistry, the company is focusing on the discovery and development of novel small molecule drugs. Their approach begins with systematically identifying approved drugs, advanced clinical candidates, or compounds that have the potential for improvement through deuterium substitution.

Unlike traditional drug discovery methods that have high failure rates, the company’s approach allows for better metabolic properties or better pharmacokinetics, thus enhancing clinical safety, efficacy, and tolerability for improved metabolic profile, bioavailability, and half-life. The company prioritizes candidate compounds according to medical needs, competitive and patent landscapes, commercial opportunity, and strategic fit.

Concert Pharmaceuticals, Inc. has executed on this particular approach in order to become a clinical stage biotechnology company. The company is developing a robust product candidate pipeline in various therapeutic areas. The company’s product candidates include CTP-499 for diabetic nephropathy, CTP-354 for spasticity associated with SCI and MS, AVP-786 for neurologic and psychiatric disorders, CTP-730 for inflammatory diseases, JZP-386 for narcolepsy, C-10068 for pain and seizures, and Deuterated Ivacaftor for CF and COPD.

Concert Pharmaceuticals, Inc. is traded in the OTC markets under the stock symbol CNCE. The company has developed the DCE Platform that consists of proprietary knowledge, information, and techniques that they have developed over the past 7 years. The company has a significant experience in pharmaceutical research and development and deuterium chemistry to product candidates that are optimally deuterated.


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Concert Pharmaceuticals, Inc. (NASDAQ:CNCE) Insiders Increased Their Holdings

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Concert Pharma's CTP-692 Positive for Schizophrenia in Phase I

Concert Pharma (CNCE) reports favorable data from the two early-stage studies on its pipeline candidate, CTP-692, currently under evaluation as an adjunctive treatment for schizophrenia. Share rise.

Concert Pharmaceuticals Reports Positive Results from Phase 1 Studies Evaluating CTP-692 in Healthy Volunteers

Concert Pharmaceuticals, Inc. (CNCE) today reported positive results from two studies in its Phase 1 program evaluating CTP-692, a novel deuterium-modified form of D-serine being developed as an adjunctive treatment for schizophrenia. Despite evidence of benefit in multiple published clinical studies of non-deuterated D-serine in the treatment of schizophrenia, its use has been limited due to renal safety concerns. Furthermore, in contrast to non-deuterated D-serine, which has been reported to display highly variable pharmacokinetic behavior in humans, CTP-692 was found to have low inter-individual pharmacokinetic variability.

Concert Pharmaceuticals Completes Enrollment in Open Label Trial to Evaluate Once-Daily vs. Twice-Daily Dosing of CTP-543 in Patients with Alopecia Areata

Concert Pharmaceuticals, Inc. (CNCE) today announced that it has completed patient enrollment of an open label clinical trial to evaluate once-daily compared to twice-daily oral dosing of CTP-543 in patients with alopecia areata. The trial is designed to inform on the optimal dosing regimen for CTP-543 for future clinical trials. Topline data from the dose regimen trial is expected in the fourth quarter of 2019.